Construction of Combinatorial “Library” of Cyclopeptides and Screening for Biological Activities

Abstract

Two combinatorial libraries of hexa- and heptacyclopeptides were synthesised by the split and mixed method. These libraries were tested for antibacterial activity against the bacterial strains $Escherichia$ $coli$ $25922$, $Escherichia$ $coli$ $35213$, $Slaphyloccus$ $aureus$ $24213$ and $Staphyloccus$ $aureus$ $29213$. Results indicated that these cyclopeptides demonstrated no activities against all four bacterial strains tested. Preliminary screening of the libraries against dengue virus protease however indicated some inhibitory activities from compounds in both libraries.Two combinatorial libraries of hexa- and heptacyclopeptides were synthesised by the split and mixed method. These libraries were tested for antibacterial activity against the bacterial strains $Escherichia$ $coli$ $25922$, $Escherichia$ $coli$ $35213$, $Slaphyloccus$ $aureus$ $24213$ and $Staphyloccus$ $aureus$ $29213$. Results indicated that these cyclopeptides demonstrated no activities against all four bacterial strains tested. Preliminary screening of the libraries against dengue virus protease however indicated some inhibitory activities from compounds in both libraries.