CRUDE POLYSACCHARIDES EFFECT OF CORIOLUS VERSICOLOR ON MYCOBACTERIUM FORTUITUM-INDUCED IMMUNE DYSFUNCTION IN MICE
DOI:
https://doi.org/10.22452/mjs.sp2019no3.4Keywords:
Coriolus versicolor, crude polysaccharides, Mycobacterium fortuitum, immune functionAbstract
Hot water extract of Coriolus versicolor contains crude polysaccharide. The active component of polysaccharide is β-glucan that can activate granulocyte, monocyte, and macrophage. Administration of crude polysaccharide against bacterial infection is expected to increase immune response. This study assessed crude polysaccharide activity in improving immune response after induction of nontuberculosis mycobacteria infection, in this case Mycobacterium fortuitum. Animal model used was female mice strain BALB/c aged 8-10 weeks. Crude polysaccharides were administered before and/or after the bacteria infection for 10 days at dose of 50 mg/kg body weight. Mice exposure to M. fortuitum was performed 2 times at dose of 0.5 Mc. Farland. After crude polysaccharide treatment, both serum and peritoneal fluid were isolated. All data collected was analyzed statistically using Anova and Duncan test. Oral administration of crude polysaccharide was found to increase phagocyte number (P<0.05, from crude polysaccharide administration before-after infection), improve phagocytic activity (P<0.05, from crude polysaccharide administration before infection), raise both IFN-g and antibody level (P<0.05, from crude polysaccharide administration after and before-after infection), but did not affect TNF-α level (P>0.05). Administration of crude polysaccharide could enhance non-specific immune response, specific immune response, and pro-inflammatory cytokine in mice infected by M. fortuitum. These results suggested that crude polysaccharide from hot water extract of C. versicolor can be applied as an effective immunostimulatory agent.
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